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Article

Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones.

Antimicrobial agents and chemotherapy - 1 Nov 2008

German Nadezhda, Malik Muhammad, Rosen Jonathan D, Drlica Karl, Kerns Robert J

Abstract excerpt

A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino...

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Identifiers

PMID: 18765690
DOI: 10.1128/AAC.00330-08
PMCID: PMC2573108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18765690-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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