Article
DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Zhao X, Xu C, Domagala J, Drlica K
Abstract excerpt
Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation of resistance suggested that new quinolones could be found that would require cells to obtain two topoisomerase mutations to display resistance. For wild-type cells to become resistant, the two mutations must be acquired concomitantly....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.