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Article

Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success.

Trends in microbiology - 1 Aug 2014

Redgrave Liam S, Sutton Sam B, Webber Mark A, Piddock Laura J V

Abstract excerpt

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have...

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Identifiers

PMID: 24842194
DOI: 10.1016/j.tim.2014.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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