Article
Quinolones: action and resistance updated.
Current topics in medicinal chemistry - 1 Jan 2009
Drlica Karl, Hiasa Hiroshi, Kerns Robert, Malik Muhammad, Mustaev Arkady, Zhao Xilin
Abstract excerpt
The quinolones trap DNA gyrase and DNA topoisomerase IV on DNA as complexes in which the DNA is broken but constrained by protein. Early studies suggested that drug binding occurs largely along helix-4 of the GyrA (gyrase) and ParC (topoisomerase IV) proteins. However, recent X-ray crystallography shows drug intercalating between the -1 and +1 nucleotides of cut DNA, with only one end of the drug extending to...
Topics
- Bacteria
- Crystallography, X-Ray
- Drug Resistance, Microbial
- Models, Molecular
- Molecular Structure
- Mutation
- Quinolones