Article
Mechanisms of drug resistance: quinolone resistance.
Annals of the New York Academy of Sciences - 1 Sept 2015
Hooper David C, Jacoby George A
Abstract excerpt
Quinolone antimicrobials are synthetic and widely used in clinical medicine. Resistance emerged with clinical use and became common in some bacterial pathogens. Mechanisms of resistance include two categories of mutation and acquisition of resistance-conferring genes. Resistance mutations in one or both of the two drug target enzymes, DNA gyrase and DNA topoisomerase IV, are commonly in a localized domain of the...
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