Article
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.
American journal of human genetics - 1 Oct 2009
DeMeo Dawn L, Mariani Thomas, Bhattacharya Soumyaroop, Srisuma Sorachai, Lange Christoph, Litonjua Augusto, Bueno Raphael, Pillai Sreekumar G, Lomas David A, Sparrow David, Shapiro Steven D, Criner Gerard J, Kim Hong P, Chen Zhihua, Choi Augustine M K, Reilly John, Silverman Edwin K
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is influenced by both genetic determinants and smoking. We identified genomic regions from 56 lung-tissue gene-expression microarrays and used them to select 889 SNPs to be tested for association with COPD. We genotyped SNPs in 389 severe COPD cases from the National Emphysema Treatment Trial and 424 cigarette-smoking...
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