RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD

Abstract excerpt

BACKGROUND: Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, alveolar macrophage and peripheral blood samples from the same subset of COPD cases and controls from the COPDGene study who underwent bronchoscopy at a single center. Using statistical and gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Asthma and respiratory diseases
• Share to Chronic Obstructive Pulmonary Disease (COPD) Research
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis