Article
The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.
BMC medical genetics - 14 Feb 2011
Chappell Sally L, Daly Leslie, Lotya Juzer, Alsaegh Aiman, Guetta-Baranes Tamar, Roca Josep, Rabinovich Roberto, Morgan Kevin, Millar Ann B, Donnelly Seamas C, Keatings Vera, MacNee William, Stolk Jan, Hiemstra Pieter S, Miniati Massimo, Monti Simonetta, O'Connor Clare M, Kalsheker Noor
Abstract excerpt
BACKGROUND: Genetic factors are known to contribute to COPD susceptibility and these factors are not fully understood. Conflicting results have been reported for many genetic studies of candidate genes based on their role in the disease. Genome-wide association studies in combination with expression profiling have identified a number of new candidates including IREB2. A meta-analysis has implicated transforming...
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