Article
The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
American journal of human genetics - 1 Feb 2006
Demeo Dawn L, Mariani Thomas J, Lange Christoph, Srisuma Sorachai, Litonjua Augusto A, Celedon Juan C, Lake Stephen L, Reilly John J, Chapman Harold A, Mecham Brigham H, Haley Kathleen J, Sylvia Jody S, Sparrow David, Spira Avrum E, Beane Jennifer, Pinto-Plata Victor, Speizer Frank E, Shapiro Steven D, Weiss Scott T, Silverman Edwin K
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin deficiency is a proven genetic risk factor for COPD. Prior linkage analyses in the Boston Early-Onset COPD Study have demonstrated significant linkage to a key intermediate phenotype of COPD on chromosome 2q. We...
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