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Article

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Respiratory research - 22 Mar 2018

Sakornsakolpat Phuwanat, Morrow Jarrett D, Castaldi Peter J, Hersh Craig P, Bossé Yohan, Silverman Edwin K, Manichaikul Ani, Cho Michael H

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability and in most cases, fail to implicate specific genes. Integrative methods that combine gene expression data with GWAS can provide more power in discovering disease-associated genes and give...

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Source

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Identifiers

PMID: 29566699
DOI: 10.1186/s12931-018-0744-9
PMCID: PMC5863845

Genes

DCBLD1
EGLN2
LILRA3
PSMA4
WNT3

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