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Article

TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia.

Haematologica - 1 Dec 2009

Kosmider Olivier, Gelsi-Boyer Véronique, Ciudad Marion, Racoeur Cindy, Jooste Valérie, Vey Norbert, Quesnel Bruno, Fenaux Pierre, Bastie Jean-Noël, Beyne-Rauzy Odile, Stamatoulas Aspasia, Dreyfus François, Ifrah Norbert, de Botton Stéphane, Vainchenker William, Bernard Oliver A, Birnbaum Daniel, Fontenay Michaëla, Solary Eric

Abstract excerpt

BACKGROUND: Acquired somatic deletions and loss-of-function mutations in one or several codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in hematopoietic cells from patients with myeloid malignancies, including myeloproliferative disorders and myelodys-plastic syndrom...

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Source

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Identifiers

PMID: 19797729
DOI: 10.3324/haematol.2009.011205
PMCID: PMC2791942

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19797729-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia.PMID 19797729Read ↗

TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele.Semantic proximity Read ↗

Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevanceSemantic proximity Read ↗

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Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevanceSemantic proximity Read ↗

TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolutionary patterns.Semantic proximity Read ↗

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.Semantic proximity Read ↗

Detection of TET2 Mutation in Patients with De Novo Acute Myeloid Leukemia: A Mutation Analysis of 51 Iranian Patients.Semantic proximity Read ↗

Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia.Semantic proximity Read ↗

TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations.Semantic proximity Read ↗

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients.Semantic proximity Read ↗

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group.Semantic proximity Read ↗

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