Article
Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia.
Blood cancer journal - 15 Jan 2016
Patnaik M M, Lasho T L, Vijayvargiya P, Finke C M, Hanson C A, Ketterling R P, Gangat N, Tefferi A
Abstract excerpt
Mutations involving epigenetic regulators (TET2~60% and ASXL1~40%) and splicing components (SRSF2~50%) are frequent in chronic myelomonocytic leukemia (CMML). On a 27-gene targeted capture panel performed on 175 CMML patients (66% males, median age 70 years), common mutations included: TET2 46%, ASXL1 47%, SRSF2 45% and SETBP1 19%. A total of 172 (98%) patients had at least one mutation, 21 (12%) had 2, 24 (14%)...
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