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Article

Detection of TET2 Mutation in Patients with De Novo Acute Myeloid Leukemia: A Mutation Analysis of 51 Iranian Patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Mar 2022

Chehreghani Zahra, Sadeghian Mohammad Hadi, Ayatollahi Hossein, Bagheri Parisa, Zafari Zahra, Rezazadeh Omid, Arbab Jafari Pourya

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous clonal disease that is considered to originate from hematopoietic stem cells, which are characterized by impaired myelopoiesis and blast proliferation. TET oncogene family member 2 (TET2) mutations are frequent in myeloid malignancies and several studies have assessed the clinical importance of TET2 mutations. However, its frequency ratio has not yet been fully...

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Identifiers

PMID: 35345350
DOI: 10.31557/APJCP.2022.23.3.803
PMCID: PMC9360970

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