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Article

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.

The American journal of psychiatry - 1 Mar 2006

Glaser Bronwyn, Debbane Martin, Hinard Christine, Morris Michael A, Dahoun Sophie P, Antonarakis Stylianos E, Eliez Stephan

Abstract excerpt

OBJECTIVE: Previous studies linking the catechol O-methyltransferase (COMT) functional polymorphism to the specific phenotype in 22q11.2 deletion syndrome (22q11.2DS) have yielded inconsistent results. The goal of the present study was to replicate a recent finding that executive function is higher in individuals hemizygous for the Met allele. METHOD: Thirty-four children and young adults with a 22q11.2...

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Source

Identifiers

PMID: 16513880
DOI: 10.1176/appi.ajp.163.3.537

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.PMID 16513880Read ↗

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Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

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COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.Semantic proximity Read ↗

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