Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.

doi:10.1371/journal.pone.0157867

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Article

Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.

PloS one - 1 Jan 2016

Narendran Rajesh, Tumuluru Divya, May Maureen A, Chowdari Kodavali V, Himes Michael L, Fasenmyer Kelli, Frankle W Gordon, Nimgaonkar Vishwajit L

Abstract excerpt

Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1 and D2/3 receptor binding potential (BP), and interpreted them in terms of dopaminergic tone. The use of baseline...

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PMID: 27322568
DOI: 10.1371/journal.pone.0157867
PMCID: PMC4913897

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COMT

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