Deep sequencing of the TP53 gene reveals a potential risk allele for non-small cell lung cancer and supports the negative prognostic value of TP53 variants.

doi:10.1177/1010428317694327

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Deep sequencing of the TP53 gene reveals a potential risk allele for non-small cell lung cancer and supports the negative prognostic value of TP53 variants.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2017

Deben Christophe, Van den Bossche Jolien, Van Der Steen Nele, Lardon Filip, Wouters An, de Beeck Ken Op, Hermans Christophe, Jacobs Julie, Peeters Marc, Van Camp Guy, Rolfo Christian, Deschoolmeester Vanessa, Pauwels Patrick

Abstract excerpt

The TP53 gene remains the most frequently altered gene in human cancer, of which variants are associated with cancer risk, therapy resistance, and poor prognosis in several tumor types. To determine the true prognostic value of TP53 variants in non-small cell lung cancer, this study conducted further research, particularly focusing on subtype and tumor stage. Therefore, we determined the TP53 status of 97...

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PMID: 28240049
DOI: 10.1177/1010428317694327

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