Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

doi:10.1007/s00251-009-0396-5

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Article

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

Immunogenetics - 1 Oct 2009

Hollenbach Jill A, Ladner Martha B, Saeteurn Koy, Taylor Kent D, Mei Ling, Haritunians Talin, McGovern Dermot P B, Erlich Henry A, Rotter Jerome I, Trachtenberg Elizabeth A

Abstract excerpt

In the present study, we investigated the relationship between the KIR loci and the genes encoding their HLA ligands and genetic susceptibility to Crohn's disease (CD). Analyses of the interactions between KIR3DL1, KIR2DL1, KIR2DL2, and KIR2DL3 with their respective HLA ligands indicate that there is a protective effect for KIR2DL2 in the absence of its HLA ligand C1. Given that KIR2DL2 and KIR2DL3 segregate as...

Topics

Adult
Alleles
California
Case-Control Studies
Cohort Studies
Crohn Disease
Genetic Predisposition to Disease
Genotype
HLA-C Antigens
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Jews

Ligands

Polymorphism, Single Nucleotide

Receptors, KIR2DL2

Receptors, KIR2DL3

Single-Blind Method

Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 19789864
DOI: 10.1007/s00251-009-0396-5
PMCID: PMC2813946

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Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.PMID 19789864Read ↗

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