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Article

Association between KIR-HLA combination and ulcerative colitis and Crohn's disease in a Japanese population.

PloS one - 1 Jan 2018

Saito Hiromi, Hirayama Atsuhiro, Umemura Takeji, Joshita Satoru, Mukawa Kenji, Suga Tomoaki, Tanaka Eiji, Ota Masao

Abstract excerpt

Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD). Natural killer cell responses play a crucial role in autoimmune disease through innate immunity, in which killer cell immunoglobulin-like receptors (KIRs) are closely involved. Although the genetic combination of KIRs with their specific HLA class I ligands has been associated with IBD in Caucasians, such KIR-HLA...

Topics

Alleles
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA Antigens
Humans
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Receptors, KIR

Source

Open in PubMed Open full text

Identifiers

PMID: 29649328
DOI: 10.1371/journal.pone.0195778
PMCID: PMC5897008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association between KIR-HLA combination and ulcerative colitis and Crohn's disease in a Japanese population.PMID 29649328Read ↗

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