Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.

doi:10.1038/sj.gene.6364333

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Article

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.

Genes and immunity - 1 Oct 2006

Jones D C, Edgar R S, Ahmad T, Cummings J R F, Jewell D P, Trowsdale J, Young N T

Abstract excerpt

Killer immunoglobulin-like receptors (KIRs) are expressed on natural killer cells and some T-cell subsets and produce either activation or inhibitory signals upon binding with the appropriate human leucocyte antigen (HLA) ligand on target cells. Recent genetic association studies have implicated KIR genotype in the development of several inflammatory conditions. Ulcerative colitis (UC) is an inflammatory disorder...

Topics

Base Sequence
Case-Control Studies
Colitis, Ulcerative
DNA Primers
Gene Frequency
Genotype
HLA Antigens
HLA-C Antigens
Humans
Killer Cells, Natural
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

NK Cell Lectin-Like Receptor Subfamily K

Phenotype

Polymorphism, Single Nucleotide

Receptors, Immunologic

Receptors, KIR

Receptors, KIR2DL2

Source

Open in PubMed

Identifiers

PMID: 16929347
DOI: 10.1038/sj.gene.6364333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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