Ha-ras oncogene mutations in cell lines derived from rat tracheal implants exposed in vivo to 7,12-dimethylbenz[a]anthracene.

doi:10.1002/mc.2940030504

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Article

Ha-ras oncogene mutations in cell lines derived from rat tracheal implants exposed in vivo to 7,12-dimethylbenz[a]anthracene.

Molecular carcinogenesis - 1 Jan 1990

Cosma G N, Wirgin I I, Marchok A C, Garte S J

Abstract excerpt

The frequency of Ha-ras mutations was determined as a function of neoplastic progression in cell lines derived from rat tracheal implants exposed in vivo to 7,12-dimethylbenz[a]anthracene. Restriction fragment-length polymorphism (RFLP) analysis revealed an A----T transversion in the second base of codon 61 in 2 of 11 cell lines. One of the positive cell lines was tumorigenic, but the other was neither...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Base Sequence
Cell Line
Codon
DNA, Neoplasm
Epithelium
Molecular Sequence Data
Mutagenesis
Mutation
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Proto-Oncogene Proteins p21(ras)

Rats

Rats, Inbred F344

Trachea

Source

Open in PubMed

Identifiers

PMID: 1978778
DOI: 10.1002/mc.2940030504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1978778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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