Article
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis.
Nature - 1 Jan 2000
Quintanilla M, Brown K, Ramsden M, Balmain A
Abstract excerpt
Cellular proto-oncogenes can be activated by both point mutations and chromosomal translocations, suggesting that there may be a direct link between exposure to agents which damage DNA and genetic change leading to malignancy. Several groups have therefore analysed mutations found in cellular oncogenes of tumours induced by particular physical or chemical carcinogens. Here, we have analysed the molecular changes...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Carcinogens
- DNA Restriction Enzymes
- Deoxyribonucleases, Type II Site-Specific
- Gene Amplification
- Methylnitronitrosoguanidine
- Mice
- Mutation
- Oncogenes
- Papilloma