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Article

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.

Molecular genetics and metabolism - 1 Jan 2010

Sangar Michelle Cook, Anandatheerthavarada Hindupur K, Martin Martha V, Guengerich F Peter, Avadhani Narayan G

Abstract excerpt

Human cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of approximately 20% of drugs in common clinical use. The CYP2D6 gene locus is highly polymorphic. Many of the polymorphisms have been shown to be clinically relevant and can account for inter-individual differences in the metab...

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Identifiers

PMID: 19781968
DOI: 10.1016/j.ymgme.2009.08.009
PMCID: PMC2794965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19781968-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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