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Article

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

Pharmacogenetics - 1 Oct 2001

Zanger U M, Fischer J, Raimundo S, Stüven T, Evert B O, Schwab M, Eichelbaum M

Abstract excerpt

Variable expression and function of the cytochrome P4502D6 (CYP2D6) leads to distinct phenotypes termed ultrarapid (UM), extensive (EM), intermediate (IM) and poor metabolizer (PM). Whereas the PM phenotype is known to be caused by two null-alleles leading to absence of functional CYP2D6 protein, the large variability among individuals with functional alleles remained largely unexplained. In this study, we...

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PMID: 11668217
DOI: 10.1097/00008571-200110000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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