Article
Cytochrome P450 CYP2D6.
IARC scientific publications - 1 Jan 1999
Wolf C R, Smith G
Abstract excerpt
Altered expression of CYP2D6 (debrisoquine hydroxylase), resulting from genetic polymorphism at the CYP2D6 gene locus, is responsible for pronounced interindividual variation in the metabolism of many clinically important drugs. Although CYP2D6 substrates are structurally diverse, most are small molecules that interact with the protein via an electrostatic interaction between a basic nitrogen which is common to...
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