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Article

Study on genotype and phenotype of novel CYP2D6 variants using pharmacokinetic and pharmacodynamic models with metoprolol as a substrate drug.

The pharmacogenomics journal - 18 Apr 2024

Qian Jianchang, Xu Tao, Pan Peipei, Sun Wei, Hu Guoxin, Cai Jianping

Abstract excerpt

To investigate the pharmacokinetic and pharmacodynamic profiles of volunteers carrying CYP2D6 genotypes with unknow metabolic phenotypes, a total of 22 volunteers were recruited based on the sequencing results. Peripheral blood and urine samples were collected at specific time points after oral administration of metoprolol. A validated high-performance liquid chromatography (HPLC) method was used to determine the...

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PMID: 38637522
DOI: 10.1038/s41397-024-00332-3

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