Article
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair.
Science signaling - 3 Dec 2019
MacKnight H Patrick, Stephenson Daniel J, Hoeferlin L Alexis, Benusa Savannah D, DeLigio James T, Maus Kenneth D, Ali Anika N, Wayne Jennifer S, Park Margaret A, Hinchcliffe Edward H, Brown Rhoderick E, Ryan John J, Diegelmann Robert F, Chalfant Charles E
Abstract excerpt
The sphingolipid ceramide 1-phosphate (C1P) directly binds to and activates group IVA cytosolic phospholipase A2 (cPLA2α) to stimulate the production of eicosanoids. Because eicosanoids are important in wound healing, we examined the repair of skin wounds in knockout (KO) mice lacking cPLA2α and in knock-in (KI) mice in which endogenous cPLA2α was replaced with a mutant form having an ablated C1P interaction...
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