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Article

Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.

The Journal of biological chemistry - 25 Sept 2009

Lamour Nadia F, Subramanian Preeti, Wijesinghe Dayanjan S, Stahelin Robert V, Bonventre Joseph V, Chalfant Charles E

Abstract excerpt

Little is known about the regulation of eicosanoid synthesis proximal to the activation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), the initial rate-limiting step. The current view is that cPLA(2)alpha associates with intracellular/phosphatidylcholine-rich membranes strictly via hydrophobic interactions in response to an increase of intracellular calcium. In opposition to this accepted mechanism of two...

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Identifiers

PMID: 19632995
DOI: 10.1074/jbc.M109.001677
PMCID: PMC2785377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.PMID 19632995Read ↗

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