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Article

Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin.

Journal of lipid research - 1 Apr 2010

Nakamura Hiroyuki, Wakita Shigeo, Suganami Akiko, Tamura Yutaka, Hanada Kentaro, Murayama Toshihiko

Abstract excerpt

We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic phospholipase A2alpha (cPLA2alpha) using two Chinese hamster ovary (CHO)-K1-derived mutants deficient in sphingolipid synthesis: LY-B cells defective in the LCB1 subunit of serine palmitoyltransferase for de novo synthesis of sphingolipid species, and LY-A cells defective in the ceramide...

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Identifiers

PMID: 19965591
DOI: 10.1194/jlr.M002428
PMCID: PMC2842140

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Source receipt: pubmed, retrieved 7 Sept 2026.

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