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Article

Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.

The Journal of biological chemistry - 9 Nov 2012

Morrison Kylee, Witte Kristen, Mayers Jonathan R, Schuh Amber L, Audhya Anjon

Abstract excerpt

Phospholipase A(2) activity plays key roles in generating lipid second messengers and regulates membrane topology through the generation of asymmetric lysophospholipids. In particular, the Group VIA phospholipase A(2) (GVIA-iPLA(2)) subfamily of enzymes functions independently of calcium within the cytoplasm of cells and has been implicated in numerous cellular processes, including proliferation, apoptosis, and...

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Identifiers

PMID: 23007400
DOI: 10.1074/jbc.M112.391508
PMCID: PMC3493924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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