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Article

Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.

Journal of the American College of Cardiology - 29 Sept 2009

Regieli Jakub J, Jukema J Wouter, Doevendans Pieter A, Zwinderman Aeilko H, Kastelein John J, Grobbee Diederick E, van der Graaf Yolanda

Abstract excerpt

OBJECTIVES: We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD). BACKGROUND: PON-1 is a potential therapeutic target to further reduce cardiovascular risk because it is a detoxifying esterase with antioxidant properties. The PON-1 knockout models result in higher susceptibility to atherosclerosis, and PON activity contributes to...

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Identifiers

PMID: 19778663
DOI: 10.1016/j.jacc.2009.05.061

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.PMID 19778663Read ↗

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