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Article

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.

PloS one - 27 Aug 2009

Birjmohun Rakesh S, Vergeer Menno, Stroes Erik S G, Sandhu Manjinder S, Ricketts Sally L, Tanck Michael W, Wareham Nicholas J, Jukema J Wouter, Kastelein John J P, Khaw Kay-Tee, Boekholdt S Matthijs

Abstract excerpt

BACKGROUND: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among...

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Identifiers

PMID: 19710913
DOI: 10.1371/journal.pone.0006809
PMCID: PMC2728540

Genes

PON1
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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