Article
Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians.
Clinical chemistry and laboratory medicine - 1 Jan 2007
Rios Domingos L S, D'Onofrio Lorenza O, Cerqueira Caio C S, Bonfim-Silva Ricardo, Carvalho Heitor G, Santos-Filho Ademar, Galvão-Castro Bernardo
Abstract excerpt
BACKGROUND: Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation. METHODS: We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who underwent coronary angiography. RESULTS: Among Caucasian-Brazilians, the homozygous 55LeuLeu...
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