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Article

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2012

Tang W H Wilson, Hartiala Jaana, Fan Yiying, Wu Yuping, Stewart Alexandre F R, Erdmann Jeanette, Kathiresan Sekar, Roberts Robert, McPherson Ruth, Allayee Hooman, Hazen Stanley L

Abstract excerpt

OBJECTIVE: Diminished serum paraoxonase and arylesterase activities (measures of paraoxonase-1 [PON-1] function) in humans have been linked to heightened systemic oxidative stress and atherosclerosis risk. The clinical prognostic use of measuring distinct PON-1 activities has not been established, and the genetic determinants of PON-1 activities are not known. METHODS AND RESULTS: We established analytically...

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Identifiers

PMID: 22982463
DOI: 10.1161/ATVBAHA.112.253930
PMCID: PMC3499946

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