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Article

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.

The Journal of cell biology - 20 Jun 2005

Shen Tang-Long, Park Ann Y-J, Alcaraz Ana, Peng Xu, Jang Ihnkyung, Koni Pandelakis, Flavell Richard A, Gu Hua, Guan Jun-Lin

Abstract excerpt

Focal adhesion kinase (FAK) is a critical mediator of signal transduction by integrins and growth factor receptors in a variety of cells including endothelial cells (ECs). Here, we describe EC-specific knockout of FAK using a Cre-loxP approach. In contrast to the total FAK knockout, deletion of FAK specifically in ECs did not affect early embryonic development including normal vasculogenesis. However, in late...

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Identifiers

PMID: 15967814
DOI: 10.1083/jcb.200411155
PMCID: PMC2171636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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