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Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and Therapy

2018-05-08

Abstract excerpt

Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 are showing promising antitumor activity, their clinical long-term efficacy may be undermined by the strong capacity of cancer cells to evade anti-kinase drugs. In healthy cells, the expression...

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Literature Corpus work
1f956060-cf30-50a1-8c12-6d2f7bc7a56a
DOI
10.20944/preprints201805.0125.v1
Open publication

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Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and TherapyDOI 10.20944/preprints201805.0125.v1
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