Article
Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization.
Yeast (Chichester, England) - 1 Dec 2009
Pereira Jorge, Pimentel Catarina, Amaral Catarina, Menezes Regina A, Rodrigues-Pousada Claudina
Abstract excerpt
Yap4 is a nuclear-resident transcription factor induced in Saccharomyces cerevisiae when exposed to several stress conditions, which include mild hyperosmotic and oxidative stress, temperature shift or metal exposure. This protein is also phosphorylated. Here we report that this modification is driven by PKA and GSK3. In order to ascertain whether Yap4 is directly or indirectly phosphorylated by PKA, we searched...
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