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Article

Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis.

Molecular and cellular biology - 1 Oct 2004

Maeta Kazuhiro, Izawa Shingo, Okazaki Shoko, Kuge Shusuke, Inoue Yoshiharu

Abstract excerpt

Methylglyoxal (MG) is synthesized during glycolysis, although it inhibits cell growth in all types of organisms. Hence, it has long been asked why such a toxic metabolite is synthesized in vivo. Glyoxalase I is a major enzyme detoxifying MG. Here we show that the Yap1 transcription factor, which is critical for the oxidative-stress response in Saccharomyces cerevisiae, is constitutively concentrated in the...

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Identifiers

PMID: 15367692
DOI: 10.1128/MCB.24.19.8753-8764.2004
PMCID: PMC516737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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