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Article

Endogenous regulation of cardiovascular function by apelin-APJ.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2009

Charo David N, Ho Michael, Fajardo Giovanni, Kawana Masataka, Kundu Ramendra K, Sheikh Ahmad Y, Finsterbach Thomas P, Leeper Nicholas J, Ernst Kavita V, Chen Mary M, Ho Yen Dong, Chun Hyung J, Bernstein Daniel, Ashley Euan A, Quertermous Thomas

Abstract excerpt

Studies have shown significant cardiovascular effects of exogenous apelin administration, including the potent activation of cardiac contraction. However, the role of the endogenous apelin-APJ pathway is less clear. To study the loss of endogenous apelin-APJ signaling, we generated mice lacking either the ligand (apelin) or the receptor (APJ). Apelin-deficient mice were viable, fertile, and showed normal...

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Identifiers

PMID: 19767528
DOI: 10.1152/ajpheart.00686.2009
PMCID: PMC2781363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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