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Article

Adaptation to exercise-induced stress is not dependent on cardiomyocyte α1A-adrenergic receptors.

Journal of molecular and cellular cardiology - 1 Jun 2021

Kaidonis Xenia, Niu Wenxing, Chan Andrea Y, Kesteven Scott, Wu Jianxin, Iismaa Siiri E, Vatner Stephen, Feneley Michael, Graham Robert M

Abstract excerpt

The 'fight or flight' response to physiological stress involves sympathetic nervous system activation, catecholamine release and adrenergic receptor stimulation. In the heart, this induces positive inotropy, previously attributed to the β1-adrenergic receptor subtype. However, the role of the α1A-adrenergic receptor, which has been suggested to be protective in cardiac pathology, has not been investigated in the...

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Source

Identifiers

PMID: 33647309
DOI: 10.1016/j.yjmcc.2021.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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