Article
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.
PloS one - 1 Jan 2015
Wang Pengyun, Xu Chengqi, Wang Chuchu, Wu Yanxia, Wang Dan, Chen Shanshan, Zhao Yuanyuan, Wang Xiaojing, Li Sisi, Yang Qin, Zeng Qiutang, Tu Xin, Liao Yuhua, Wang Qing K, Cheng Xiang
Abstract excerpt
Heart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar role in humans is unknown. We studied a functional variant, rs9943582 (-154G/A), at the 5'-untranslated region, that...
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