Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

Article

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

Cancer research - 15 Feb 1990

Shibata D, Almoguera C, Forrester K, Dunitz J, Martin S E, Cosgrove M M, Perucho M, Arnheim N

Abstract excerpt

Formalin-fixed paraffin-embedded tissue specimens obtained by fine needle aspiration of pancreatic masses from 47 patients were examined retrospectively for cytology and the presence of mutant c-K-ras oncogenes. Point mutations of c-K-ras in codon 12 were detected by RNA-DNA RNAse A mismatch clea...

Topics

Adenocarcinoma
Biopsy, Needle
Codon
Genes, ras
Humans
Mutation
Pancreatic Neoplasms
Polymerase Chain Reaction
RNA, Messenger
Retrospective Studies

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