Article
Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations.
Breast cancer research and treatment - 1 Jul 2010
Hollestelle Antoinette, Elstrodt Fons, Timmermans Mieke, Sieuwerts Anieta M, Klijn Jan G M, Foekens John A, den Bakker Michael A, Schutte Mieke
Abstract excerpt
Mutations of E-cadherin have been identified in half of lobular breast cancers and diffuse-type gastric cancers, two tumor subtypes with remarkably similar pathological appearances including small rounded cells with scant cytoplasm and a diffuse growth pattern. A causal role for E-cadherin gene mutations in the lobular breast cancer phenotype was recently demonstrated in E-cadherin knock-out mice. These...
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