Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.

Experimental cell research - 1 Jan 2008

Fuchs Margit, Hermannstädter Christine, Hutzler Peter, Häcker Georg, Haller Ferdinand, Höfler Heinz, Luber Birgit

Abstract excerpt

E-Cadherin-mediated cell-cell adhesion plays a key role in epithelial cell survival and loss of E-cadherin or beta-catenin expression is associated with invasive tumor growth. Somatic E-cadherin mutations have been identified in sporadic diffuse-type gastric carcinoma. Here, we analysed the fate of E-cadherin with an in frame deletion of exon 8 compared to wild-type E-cadherin and the involved signalling events...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Adherens Junctions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to beta Catenin

Share to Cadherins

Share to Cell Adhesion

Share to Cisplatin

Share to Cytoskeleton

Share to Neoplasm Invasiveness

Source

Identifiers

PMID: 17959171
DOI: 10.1016/j.yexcr.2007.09.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.PMID 17959171Read ↗

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Semantic proximity Read ↗

Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast.Semantic proximity Read ↗

Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.Semantic proximity Read ↗

Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online.Semantic proximity Read ↗

Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro.Semantic proximity Read ↗

Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate.Semantic proximity Read ↗

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invadeSemantic proximity Read ↗

Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma.Semantic proximity Read ↗

Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations.Semantic proximity Read ↗

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.Semantic proximity Read ↗

CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.Semantic proximity Read ↗

Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.