Article
Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines.
International journal of cancer - 20 Mar 2001
Woo D K, Kim H S, Lee H S, Kang Y H, Yang H K, Kim W H
Abstract excerpt
beta-catenin serves not only as a structural component of the E-cadherin-mediated cell-cell adhesion system, but also as a signaling molecule of the Wnt/wingless pathway. Deregulated expression of beta-catenin and mutations of the gene have been identified in a number of human malignancies. To determine the role of beta-catenin defects in stomach cancer, we investigated beta-catenin exon 3 mutations and altered...
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