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Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

Cancer research - 1 Jan 2001

van de Wetering M, Barker N, Harkes I C, van der Heyden M, Dijk N J, Hollestelle A, Klijn J G, Clevers H, Schutte M

Abstract excerpt

Participation of E-cadherin in the Wnt signaling pathway was suggested because of the dual role of beta-catenin in cell adhesion and the Wnt signaling cascade. Whereas beta-catenin interacts at the cell membrane with the cell adhesion protein E-cadherin, in the nucleus it activates Wnt target genes through formation of transcriptionally active complexes with members of the Tcf/Lef family of transcription factors....

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PMID: 11196175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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