Article
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.
Oncogene - 7 Nov 1996
Berx G, Cleton-Jansen A M, Strumane K, de Leeuw W J, Nollet F, van Roy F, Cornelisse C
Abstract excerpt
We have analysed a series of 49 human breast cancers for mutations in the entire coding region plus flanking intron sequences of the E-cadherin gene. The tumours included 41 infiltrating lobular carcinomas, two infiltrating ducto-lobular carcinomas and six infiltrative ductal carcinomas. In the l...
Topics
- Binding Sites
- Breast Neoplasms
- Cadherins
- Carcinoma, Lobular
- Chromosomes, Human, Pair 16
- DNA Mutational Analysis
- Heterozygote
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Mutation
- Neoplasm Invasiveness
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA