Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.

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Article

Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.

Oncogene - 5 Oct 1995

Pierceall W E, Woodard A S, Morrow J S, Rimm D, Fearon E R

Abstract excerpt

Alterations in intercellular junction and membrane cytoskeletal proteins may underlie some of the morphological, invasive and metastatic properties of cancer. E-cadherin, a transmembrane protein that functions in epithelial cell-cell interactions at adherens junctions, is linked to the membrane cytoskeletal matrix through interactions with alpha- and beta-catenin. We have carried out studies of E-cadherin and...

Topics

Base Sequence
Blotting, Southern
Blotting, Western
Breast Neoplasms
Cadherins
Cytoskeletal Proteins
Female
Gene Deletion
Gene Expression
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Receptor, ErbB-2

Ribonucleases

Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 7478552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478552-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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