Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.

PloS one - 30 Nov 2010

Bonetti Diego, Clerici Michela, Manfrini Nicola, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

The ends of both double-strand breaks (DSBs) and telomeres undergo tightly regulated 5' to 3' resection. Resection of DNA ends, which is specifically inhibited during the G1 cell cycle phase, requires the MRX complex, Sae2, Sgs1 and Exo1. Moreover, it is negatively regulated by the non-homologous end-joining component Yku and the telomeric protein Rif2. Here, we investigate the nuclease activities that are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleases
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endodeoxyribonucleases

Share to Exodeoxyribonucleases

Share to G1 Phase

Share to G2 Phase

Share to RecQ Helicases

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21152442
DOI: 10.1371/journal.pone.0014142
PMCID: PMC2994746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.PMID 21152442Read ↗

DNA End Resection: Facts and MechanismsSemantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.Semantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forksSemantic proximity Read ↗

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-NucleaseSemantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.Semantic proximity Read ↗

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.