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Article

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.

Nature - 27 Sept 2012

Costelloe Thomas, Louge Raphaël, Tomimatsu Nozomi, Mukherjee Bipasha, Martini Emmanuelle, Khadaroo Basheer, Dubois Kenny, Wiegant Wouter W, Thierry Agnès, Burma Sandeep, van Attikum Haico, Llorente Bertrand

Abstract excerpt

Several homology-dependent pathways can repair potentially lethal DNA double-strand breaks (DSBs). The first step common to all homologous recombination reactions is the 5'-3' degradation of DSB ends that yields the 3' single-stranded DNA required for the loading of checkpoint and recombination proteins. In yeast, the Mre11-Rad50-Xrs2 complex (Xrs2 is known as NBN or NBS1 in humans) and Sae2 (known as RBBP8 or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22960744
DOI: 10.1038/nature11353
PMCID: PMC3493121

Genes

SMARCAD1
EXO1
NBN
RBBP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2Semantic proximity Read ↗

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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous RecombinationSemantic proximity Read ↗

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