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Article

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Safa A R, Stern R K, Choi K, Agresti M, Tamai I, Mehta N D, Roninson I B

Abstract excerpt

Expression of P-glycoprotein, encoded by the human MDR1 gene, results in cross-resistance to many lipophilic cytotoxic drugs (multidrug resistance). P-glycoprotein is believed to function as an energy-dependent efflux pump that is responsible for decreased drug accumulation in multidrug-resistant cells. Previous work showed that preferential resistance to colchicine in a colchicine-selected multidrug-resistant...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Cell Survival
Colchicine
Drug Resistance
Glycine
Humans
KB Cells
Kinetics
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Neoplasm Proteins

Protein Binding

Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 1976255
DOI: 10.1073/pnas.87.18.7225
PMCID: PMC54716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.PMID 1976255Read ↗

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